Ho Lab @ academia Sinica

My lab is dedicated to the visualization of protein function, using protein crystallography, cryo-EM, and small angle X-ray scattering (SAXS) as main experimental tools. Currently, my laboratory focuses on two different areas of biology: 1) molecular mechanism and regulation of eukaryotic recombinases in maintaining genome stability, and 2) bacteriophage-mycobacterium interaction at the molecular level to aid phage therapy. In addition, we also study plant gene response under submergence stress focusing on protein-protein interactions and provide our cryo-EM expertise and collaborate with others in solving cryo-EM structure of protein machinery, including phycobilisome, virus-like-particles, metabolic enzymes and etc. The unifying principle in our research is the study of protein function by direct visualizing of their function state, protein architecture and assembly, and regulatory (or substrate) interactions.