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DNA repairing:Rad51

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Luo SC, Yeh MC, Lien YH, Yeh HY, Siao HL, Tu IP, Chi P, Ho MC*. A RAD51–ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination. Nat. Commun. 2023, 14:4933

Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Li HW, Ho MC*, Chi P*, Tsai MD*. Identification of fidelity-governing factors inhuman recombinases DMC1 and RAD51 from cryo-EM structures. Nat. Commun. 2021, 12:115

Phage

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Cancer drug:PRMT5

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Fulton M, Cao M, Ho MC, Zhao X, Zheng YG. The Macromolecular Complexes of Histones Affect Protein Arginine Methyltransferase Activities. JBC 2021 297(4):101123

Qian K, Yan C, Su H, Dang T, Zhou B, Wang Z, Zhao X, Ivanov I, Ho MC, and Zheng YG. Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases. RSC Med. Chem. 2021, 12(1): 95–102.

Tewary SK, Zheng YG, Ho MC*. Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level. Cell. Mol. Life Sci. 2019, 76(15): 2917-2932

FultonMD, Zhang J, He M., Xu H, Ho MC, Zhang YG. The Intricate Effects of α-Amino and Lysine Modifications on Arginine Methylation on the Histone H4 N-terminal Tail. Biochemistry 2017, 56:3539-48

Yan L, Yan C, Qian K, Su H, Kofsky-Wofford SA, Lee WC, Zhao X, Ho MC, Ivanov I, Zheng YG, Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J. Med. Chem. 2014, 57:2611-12

Lee WC, Lin WL, Matsui T, Chen ES, Wei TY, Lin WH, Hu H, Zheng YG, Tsai MD, Ho MC*. Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity. Biochemistry 2015, 54:7514-23(cover article)

Hu H, Qian K, Ho MC, Zheng YG. Small Molecule Inhibitors of Protein Arginine Methyltransferases. Expert Opin. Investig. Drugs 2016, 25:335-58

Rice flooding-resistance

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Lin CC, Lee WJ, Zheng CY, Chou MY, Lin TJ, Lin CS, Ho MC*, Shih MC*. SUB1A-1 anchors a regulatory cascade for epigenetic and transcriptional controls of submergence tolerance in rice. PNAS Nexus 2023, 2:1-13

Lin CC, Chao Y, Chen WC, Ho HY, Chou MY, Li YR, Wu YK, Yang HA, Hsieh H, Kin CS, Wu FH, Chou SJ, Jen HC, Huang YH, Irene D, Wu WJ, Wu JL, Gibbs DJ, Ho MC*, Shih MC*. Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence. Proc. Natl. Acad. Sci. U.S.A. 2019, 116 (8): 3300-3309

Others

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Jian HW, Wu HY, Wang CH, Yang CH, Ko JT, Ho HC, Tsai MD, Bryant D, Li FW, Ho MC*, Ho MY*. A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat. Commun. 2023, 14:8009

EswarKumar N, Yang CH, Tewary S, Peng WH, Chen GC, Yeh YQ, Yang HC*, Ho MC*. An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation. Structure 2023, 31:1567-1577

Chou MC, Wang YH, Chen FY, Kung CY, Wu KP, Kuo JC, Chan SJ, Cheng ML, Lin CY, Chou YC, Ho MC, Firestine S, Huang JR, Chen RH. PAICS ubiquitination recruits UBAP2 to trigger liquid-liquid phase separation for purinosome assembly. Mol. Cell 2023, 83(22):4123-4140

Chiu YC, Yeh MC, Wang CH, Chen YA, Chang H, Lin HY, Ho MC, Lin SM. Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin Nat. Commun. 2023, 14: 5946

Chen Eric HL, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC*, Chen Rita PY*. Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography. Nat. Commun. 2023, 14: 5464

Lu KJ, Chang CW, Wang CH, Chen F, Huang I, Huang PH, Yang CH, Wu HY, Wu WJ, Hsu KC, Ho MC, Tsai MD, Liao J. An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria. Nat. Metab. 2023, 8(4):695-710

Hsieh JY, Chen KC, Wang CH, Liu,GY, Ye JA, Lin YC, Lyu CJ, Chang RY, Liu YL, Li YH, Lee MR, Ho MC*, Hung HC*, Suppression of the Human Malic Enzyme (ME2) Modifies Energy Metabolism and Inhibits Cellular Respiration. Commun. Biol. 2023, 6: 548

Lai L, Cheung YW, Martinez M, Kixmoeller K, Palao 3rd L, Steimle S, Ho MC, Black BE, Lai EM, Chang YW. In Situ Structure Determination of Bacterial Surface Nanomachines Using Cryo-Electron Tomography. Methods Mol Biol. 2023, 2646:211-248

Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC*, Chen CJ*. Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions. Nat. Commun. 2023, 14: 545.

Shih O., Liao KF., Yeh YQ., Su CJ., Wang CA., Chang JW., Wu WR., Liang CC., Lin CY., Lee TH., Chang CH., Chiang LC., Chang CF., Liu DG., Lee MH., Liu CY., Hsu TW., Mansel B., Ho MC., CY, Lee F., Yen E., Lin TC. and Jeng U. Performance of the new biological small- and wide-angle X-ray scattering beamline 13A at the Taiwan Photon Source. J. Appl. Cryst, 2022. 55: 340-352

Tsai MD, Wu WJ, Ho MC. Enzymology and Dynamics by Cryogenic Electron Microscopy. Annu. Rev. Biophys. 2022, 51: 19-38

Hsieh JY, Cheng HC, Tewary SK, Yang HP, Liu YL, Tai SC, Chen WL, Hsu CH, Huang TJ, Chou CJ, Huang YN, Peng CT, Ho MC*, Liu GY*, Hung HC*. Single nucleotide polymorphisms lead to dysregulation of the human mitochondrial NAD(P)+-dependent malic enzyme. iScience 2021, 24(2):102034

Liu YM, Shahed-Al-Mahmud MD, Chen X, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C. A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2. Cell Rep. 2020 32(6): 108016

Anandharaj M, Lin YJ, Rani RP, Nadendla EK, Ho MC, Huang CC, Cheng JF, Chang JJ, Li WH. Constructing a yeast to express the largest cellulosome complex on the cell surface. Proc. Natl. Acad. Sci. U.S.A. 2020, 117(5): 2385-2394

Liang PH, Lin WL, Hsieh HY, Lin TY, Chen CH, Tewary SK, Lee HL, Yuan SF, Yang B, Yao JY, Ho MC*. A flexible loop for mannan recognition and activity enhancement in a bifunctional glycoside hydrolase family 5. BBA-general subjects 2018, 1862:513

Wu WL, Chen MY, Tu IF, Lin YC, Eswarkumar N, Chen MY, Ho MC*, Wu SH*. The discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles. Sci. Rep. 2017, 7:4658

Liu MS, Tsai HY, Liu XX, Ho MC, Wu WJ, Tsai MD. Structural Mechanism for the Fidelity Modulation of DNA Polymerase λ. J. Am Chem Soc 2016, 138:2389-98

Yuan SF, Wu TH, Lee HL, Hsieh HY, Lin WL, Yang B, Chang CK, Li Q, Gao J, Huang CH, Ho MC*, Guo RT*, Liang PH*, Biochemical Characterization and Structural Analysis of a Bifunctional Cellulase/Xylanase from Clostridium thermocellum. J. Biol. Chem. 2015, 290(9): 5739-48

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